HIV Super Infection Study (HISIS)

 

Decription

basing on samples obtained from 600 prostitutes in during the HISIS study, correlates of protective immunity are evaluated. In a case-control-study, cellular immunity is examined using ELISPOT and intracellular cytokine staining (ICC) in three subgroups:
Women massively exposed to HIV during three years as prostitutes, who are HIV-negative;
Women infected with HIV once, whose immune response is preventing superinfection with another HIV strain;
Women whose immune response is insufficient to prevent infection, resulting in several infections with HIV.
Thus, correlates of protective immunity shall be identified. First results how certain HLA alleles (B5801, B8101, B0702) to induce a borader immunity in gag, which contributes to a long-term reduction in viral load by two log steps.

LMU Department of Infectious Diseases and Tropical Medicine is participating in this activity through its immunologists L. Podola, PhD and C. Geldmacher, PhD, who are planning and analysing this study together with colleagues in the NIMR-MMRC immunology laboratory.

Project Coordinator: L. Maboko

You can reach us at:

NIMR - Mbeya Medical Research Center
P.O Box 2410
Hospital Hill rd, Mbeya Tanzania

Tel +255 25 250 3364
Fax +255 25 250 3134

Working hours:
Mon - Fri
08:00 - 17:00 EAT (GMT + 3)

Or send us an email at This email address is being protected from spambots. You need JavaScript enabled to view it.

Our Twitter Feed

NIMRMbeya RT @NIMR_Tanzania: NIMR Director General, Prof. Aboud, leading the MUHAS @muhimbiliuniver and @NIMRMbeya PrEPVacc trial team at the PrEPVac…
2hreplyretweetfavorite
NIMRMbeya RT @NIMR_Tanzania: Mtafiti Mkuu Kiongozi wa kituo cha NIMR-Tanga, Prof. John Lusingu, akipanda mti katika kuunga mkono kampeni ilioanzishwa…
4hreplyretweetfavorite
NIMRMbeya Our @PrEPVacc study team and a representative from our Community Advisory Board (CAB) attending the PrPEVacc Conso… https://t.co/KrToVDqrqW
4hreplyretweetfavorite
NIMRMbeya RT @unicef_aids: [🚨 Outcome of the #GlobalAlliance] Tanzania's Minister of Health @ummymwalimu presenting the newly adopted Dar es Salaam…
6hreplyretweetfavorite
NIMRMbeya RT @IpyanaMwakyusa1: A collective effort is needed to make the community safe from disease.Congrats to PrEPVacc for the efforts to see how…
6hreplyretweetfavorite
© 2017 NIMR - Mbeya Medical Research Center