The OEBA Study: Observation of Early Bactericidal Activity of Standard TB Treatment

A PanACEA Capacity Development Project

MMRC: Site Principal Investigator: Andrea Rachow, MD, Co-Site PI: Issa Sabi

Munich: Protocol Chair: Norbert Heinrich

Purpose
Early Bactericidal Activity (EBA) Studies are currently the eye of the needle in the anti-TB drug development process, with limited site capacity slowing down phase 2 testing of new anti-TB drug candidates. To address this problem, PanACEA (Pan-African Consortium for Evaluation of Antituberculosis Antibiotics) has decided to develop a Tanzanian EBA facility consisting of MMRC and Kilimanjaro Clinical Research Institute (KCRI).

OEBA is designed as a platform to establish capacity for Early Bactericidal Activity Studies in these sites, and will provide the opportunity to research additional questions around TB treatment and monitoring of treatment success.

 

Approach
The sites are developing their inpatient facilities, train laboratory and clinical staff, and demonstrate the capabilities within this two-site study, which will apply the methodologies to patients newly started on standard anti-TB treatment. The results of this study will demonstrate that EBA studies are feasible in the two-site setting in Tanzania.

Results
Tthe protocol has been finalized in 3Q 2010, and is currently undergoing ethical review.

Sponsors
Tthe study is sponsored by the European and Developing Countries Clinical Trials Partnership (EDCTP), within the PanACEA capacity development plan.

Partners
Kilimanjaro Clinical Research Institute, Radboud University Nijmegen, the Netherlands, University College of London

Publications
no publications yet

You can reach us at:

NIMR - Mbeya Medical Research Center
P.O Box 2410
Hospital Hill rd, Mbeya Tanzania

Tel +255 25 250 3364
Fax +255 25 250 3134

Working hours:
Mon - Fri
08:00 - 17:00 EAT (GMT + 3)

Or send us an email at This email address is being protected from spambots. You need JavaScript enabled to view it.

Our Twitter Feed

NIMRMbeya Maria Mwakatima reviewing an article by Kyle D. Smith et al on "Increased Antifungal Drug Resistance in Clinical Is… https://t.co/9Z2GYTiZPp
NIMRMbeya Dr. Elimina Siyame facilitating a study review by Tumaini J. Nagu et al on the association between anaemia and dela… https://t.co/b6ZQFJtcMw
NIMRMbeya Dr. Issa Sabi akitoa mafunzo kuhusu tafiti za Kifua Kikuu kwa wajumbe we MKUTA (Mapambano dhidi ya Kifua Kikuu na U… https://t.co/uYaR3Wa4JR
NIMRMbeya Watafiti na wajumbe wa CAB wakiwa kwenye maaandamano katika kuadhimisha siku ya Ufahamu wa Chanjo ya VVU Duniani.… https://t.co/c2yxq7sY2p
NIMRMbeya Wananchi na wakazi wa Mbalizi wakiwa katika foleni ya kupatiwa huduma ya upimaji wa VVU kwa hiari. #HVAD @NIMRHQS,… https://t.co/V7pJc2fsDg
© 2017 NIMR - Mbeya Medical Research Center