The MMRC Immunology department has been established in 2002/2003 in a collaborative effort between the MMRC, the Ludwig-Maximilians University of Munich and the US Military HIV Research Program. The main objective was to set up a state-of-the art cellular immunology laboratory for immunogenicity studies during HIV vaccine trials and to train and support young Tanzanian scientists with genuine interest in the field of Infection & Immunity.
Current areas of research:
|Current Team members:
Dr. Mkunde Chachage, PhD, Supervisor
Dr. Asli Bauer, PhD, Supervisor
Antelmo Haule, BSc (Hons), Section Supervisor
Maria Mwakatima, Research Scientist
Lwitiho Sudi, Research Scientist
Jacqueline Mhidze, Research Scientist
Jonathan Mnkai, Research Scientist
Prisca Mviombo, Laboratory technician
Wolfram Mwalongo, Laboratory Technician
Dr. Christof Geldmacher, PhD, LMU, Scientific advisor
Selected scientific publications
- Assessment of the novel T-cell activation marker-tuberculosis assay for diagnosis of active tuberculosis in children: a prospective proof-of-concept study. Portevin et al. Lancet. Infect. Dis. 2014;3099(14): 1–8
- Helminth-associated systemic immune activation and HIV co-receptor expression: Response to Albendazole/Praziquantel treatment. Chachage et al. PLoS Negl. Trop. Dis. 2014;8(3):e2755
- Preferential infection and depletion of Mycobacterium tuberculosis (MTB)-specific CD4 T cells after HIV-1 infection. Geldmacher & Ngwenyama et al. J. Exp. Med 2010; 207: 2869–2881
- CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients. Geldmacher et al. J Virol. 2007 Mar; 81(5):2440-8.
- Minor viral and host genetic polymorphisms can dramatically impact the biological outcome of an epitope-specific CD8 T cell response. Geldmacher et al. Blood 2009 Aug 20;114(8):1553-62.
- Early Depletion of Mycobacterium tuberculosis–Specific T Helper 1 Cell Responses after HIV-1 Infection. Geldmacher et al. J Infect Dis. 2008 Dec 1;198(11):1590-8
- In a mixed subtype epidemic, the HIV-1 Gag-specific T-cell response is biased towards the infecting subtype. Geldmacher et al. AIDS 2007 Jan 11; 21(2):135-43.
- A high viral burden predicts the loss of CD8 T-cell responses specific for subdominant gag epitopes during chronic human immunodeficiency virus infection. Geldmacher et al. J Virol. 2007 Dec; 81(24):13809-15.