Dr. Mkunde Chachage

HoU:laboratory sciences (Immunology)

 mkunde

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PhD -  University name and year of graduation: Ludwig-Maximilians-Universitӓt München (LMU), Germany. 2014

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Immunology of infectious diseases with focus on HIV pathogenesis, co-infections and HIV interventions (vaccinology and cure studies).

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    • German Research Foundation (DFG). Project Title: “Dissecting the effects of filarial‐associated immunomodulation on HIV susceptibility.” Grantholders: Prof. Achim Hoerauf (University of Bonn, Germany); Inge Kroidl (LMU, Germany); Alex Debrah (Kwame Nkrumah University of Science and Technology, Ghana) and Mkunde Chachage (NIMR-MMRC, Tanzania). Amount awarded: 564,519€. Applicant’s role: Co-investigator and coordinator of study activities in Tanzania. Period of support: 2017-2019. Project description: This study aims to examine the altered immunological responses that are associated with increased HIV susceptibility in filarial infected individuals from Tanzania and Ghana.

    • Center for International Health (CIH,LMU) competitive network funds. Project Title: International symposium on “Linking programmatic, clinical and biomedical research activities to reduce Cervical Cancer burden in sub-Saharan Africa." Grantholders: Drs. Mkunde Chachage and Ruby Mcharo (NIMR-MMRC, Tanzania). Amount awarded: 24,000€. Applicant’s role: Lead applicant. Period of support: 2015. Project description: This competitive grant was awarded to organize a Pan-African symposium on strategies to reduce cervical cancer in sub-Saharan Africa--which was held successfully in November 2015 in Mbeya, Tanzania.

    • German Center for Infection Research (DZIF) investment funds. Project Title: “Upgrade Biobank and processing at NIMR-MMRC.” Grantholders: Christof Geldmacher, Arne Kroidl (LMU, Germany) and Mkunde Chachage (NIMR-MMRC, Tanzania). Amount awarded: 99,400€. Applicant’s role: Co-applicant. Period of support: 2017. Project description: This competitive grant was awarded to improve the bio-banking capacity of NIMR-MMRC laboratories in Mbeya, Tanzania.

    • HVTN Initiatives Program (HIP) grant (National Institute of Allergy and Infectious Diseases (NIAID) funds). Project Title: “Pilot study for systematic comparison of HIV vaccine-induced immune responses between Caucasian and African populations.” Grantholders: Mkunde Chachage (NIMR-MMRC, Tanzania) and Edna Viegas (INS, Mozambique). Amount awarded: $75,000. Applicant’s role: Co-applicant. Period of support: 2017-2018. Project description: This competitive grant was awarded to compare HIV vaccine-induced immune responses between Caucasian and African populations to be able to inform new clinical trials designs conducted in different populations. The project also aims to increase the capacity for immunogenicity/immunomonitoring studies at African Institutions.

    • Center for International Health (CIH,LMU) competitive network funds: “Premature accelerated ageing in Young HIV-infected individuals: Global research initiative." Grantholders: Francesco Nicoli (University of Ferrara, University of Padua, Italy) Mkunde Chachage (NIMR-MMRC, Tanzania), Deepak Paudel (Save the Children, Nepal) and María Teresa Solis Soto (San Francisco Xavier de Chuquisaca University, Bolivia). Amount awarded:  18,630€. Applicant’s role: Co-applicant. Period of support: 2017-2018. Project description: This competitive grant was awarded to facilitate an international network between collaborators as well as creation of preliminary data that will initiate a study aimed at assessing premature biological ageing in HIV infected children.

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F. Nicoli , E. Gallerani, F. Sforza, V. Finessi, M. Chachage, C. Geldmacher, A. Cafaro, B. Ensoli, A. Caputo, R. Gavioli. “The HIV-1 Tat protein affects human CD4+ T-cell programing and activation, and favors the differentiation of naïve CD4+ T cells.” AIDS. 2018;32(5):575-581. https://www.ncbi.nlm.nih.gov/pubmed/29280760

Stephen Opat, Anna Hearps, Kevin Thia, Agnes Yuen, Ben Rogers, Mkunde Chachage, Gregory Moore, Jake Shortt, Georgina Ryland, Piers Blombery, Anthony P. Schwarer, Tahereh Noori, Joseph A. Trapani, Anthony Jaworowski and Ilia Voskoboinik.  Adaptive reprogramming of NK cells in X-linked lymphoproliferative syndrome. Blood. 2017; 08:803668. https://www.ncbi.nlm.nih.gov/pubmed/29233820

Anna C Hearps, Paul A Agius, Jingling Zhou, Samantha Brunt, Mkunde Chachage, Thomas A Angelovich, Paul U Cameron, Michelle Giles, Patricia Price, Julian Elliott and Anthony Jaworowski. “Persistence of Activated and Adaptive-Like NK Cells in HIV+ Individuals despite 2 Years of Suppressive Combination Antiretroviral Therapy.” Frontiers in Immunology. 2017; 8:731. https://www.frontiersin.org/articles/10.3389/fimmu.2017.00731/full

Chachage, G. Pollakis, E. O. Kuffour, K. Haase, A. Bauer, Y. Nadai, L. Podola, P. Clowes, M. Schiemann, L. Henkel, D. Hoffmann, S. Joseph, S. Bhuju, L. Maboko, F. S. Sarfo, K. Eberhardt, M. Hoelscher, T. Feldt, E. Saathoff and C. Geldmacher. CD25+FoxP3+ memory CD4 T cells are frequent targets of HIV infection in vivo. J. Virol. 2016; 90(20): 8954-67. https://www.ncbi.nlm.nih.gov/pubmed/27384654

Nicoli & M. Chachage*, P. Clowes, A. Bauer, D. Kowour, B. Ensoli, A. Cafaro, L. Maboko, M. Hoelscher, R. Gavioli, E. Saathoff, C. Geldmacher. Association between different anti-Tat antibody isotypes and HIV disease progression: data from an African cohort. BMC Infect. Dis. 2016; 16(1):344. https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-1647-3

Chachage, L. Podola, P. Clowes, A. Nsojo, A. Bauer, O. Mgaya, D. Kowour, G. Froeschl, L. Maboko, M. Hoelscher, E. Saathoff and C. Geldmacher. Helminth-associated systemic immune activation and HIV co-receptor expression: Response to Albendazole/Praziquantel treatment. PLoS Negl. Trop. Dis. 2014;8(3):e2755. http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002755

Chachage and C. Geldmacher. Chapter: Immune system modulation by Helminth infections: Potential impact on HIV transmission and disease progression. In: How Helminths Alter Immunity to Infection. Ed: William Horsnell. Advances in Experimental Medicine and Biology. 2014; 828: 131-149. https://www.ncbi.nlm.nih.gov/pubmed/25253030

Portevin, F. Moukambi, P. Clowes, A. Bauer, M. Chachage, N. E. Ntinginya, E. Mfinanga, K. Said, F. Haraka, A. Rachow, E. Saathoff, M. Mpina, L. Jugheli, F. Lwilla, B. J. Marais, M. Hoelscher, C. Daubenberger, K. Reither, and C. Geldmacher. Assessment of the novel T-cell activation marker-tuberculosis assay for diagnosis of active tuberculosis in children: a prospective proof-of-concept study. Lancet. Infect. Dis. 2014;3099(14): 1–8. https://www.ncbi.nlm.nih.gov/pubmed/25185458

D. Portevin, F. Moukambi, M. Mpina, A. Bauer, F. Haraka, M. Chachage, P. Metzger, E. Saathoff, P. Clowes, N. E. Ntinginya, A. Rachow, M. Hoelscher, K. Reither, C. Daubenberger, C. Geldmacher. Maturation and Mip-1β Production of Cytomegalovirus-Specific T Cell Responses in Tanzanian Children, Adolescents and Adults: Impact by HIV and Mycobacterium tuberculosis Co-Infections. PloS one. 2015;10(5), p.e0126716. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126716

M. J. Jansen van Rensburg; V. E. Madikane; A. Whitelaw; M. Chachage; S. Haffejee; B. G. Elisha. The Dominant Methicillin‐Resistant Staphylococcus aureus Clone from Hospitals in Cape Town has an Unusual Genotype: ST612. Clin Microbiol Infect. 2011; 17: 785–792. https://www.ncbi.nlm.nih.gov/pubmed/20854426

 

*Joint first authorship: Nicoli et al., 2016

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2017-Present                      Pathogenesis and risk factors of long-term sequelae of pulmonary TB defining individual outcomes and public health impact (TB Sequelae)

2017-Present                      Premature accelerated ageing in Young HIV-infected individuals: Global research initiative (PLAY HIGH)

2017-Present                      Pilot study for systematic comparison of HIV vaccine-induced immune responses between Caucasian and African populations

2017-Present                      Dissecting the effects of filarial‐associated immunomodulation on HIV susceptibility (RHINO)

2013-Present                     Case-control study to identify risk factors associated with Human Papilloma Virus (HPV) associated lesions within the female reproductive tract (2H study)

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