Daniela Höfler

Daniela Höfler is a post-doctorate researcher department of Molecular Diagnostics of Oncogenic Infections, German Cancer Research Center (DKFZ), Heidelberg, Germany. Dr. Höfler completed her education in Germany where she studied Biology at Ruprecht-Karls-university and subsequently, attained a PhD with a thesis on “HPV16 RNA patterns as diagnostic marker for cervical cancer precursor lesions: Validation by newly developed high-throughput RT-qPCR” at DKFZ, Heidelberg, Germany. She is part of Dr. Michael Pawlita’s research group whose research focuses on “Molecular Diagnostic of Oncogenic Infections” –specifically, on the association of specific infections with human cancers. The group has pioneered the development of a high-throughput multiplex serology and genotyping technologies. Dr. Höfler’s current research interest comprises mainly the development and validation of molecular assays for the detection of HPV and its application in precancerous lesion screening. As part of her PhD thesis, she developed a second generation of HPV16 RNA patterns quantifying 3 viral transcripts (E6*I, E1^E4 and E1C) in two separate RT-qPCR. Late stages of HPV-induced cervical lesions need immediate diagnostic procedures and if verified treatment. HPV16 RNA patterns could be shown to be specific for these late stages and could help to sensitively identify them. In future, her group is planning to extend the HPV16 RNA patterns to other 7 high-risk HPV types, to validate the HPV RNA patterns as Triage test for HPV DNA-positive women and to apply the HPV RNA patterns to other cancer entities with HPV involvement. Most of her work has been published in a number of peer-reviewed journals. Dr. Höfler and her group are also actively involved in external monitoring of HPV genotyping procedures that are carried out at NIMR-MMRC.

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